About 10% of CNS cryptococcosis in India is caused by Cryptococcus gattii with 80% mortality
September 13 2017
About 10% of CNS cryptococcosis in India is caused by Cryptococcus gattii in a prospective 3 year study conducted by Shayanki Mukhopadhyay and colleagues at the National Institute of Mental Health and Neuro Sciences, Bangalore, India. A total of 199 cases of CNS cryptococcosis were diagnosed between January 2012 and December 2015, 20 (10%) of which were due to C. gattii. Most 75% (n=15) of the C. gattii-infected patients presented with meningitis and 25% (n=5) with a cryptococoma. Mortality was 80% in both cryptococcoma (4/5) and meningitis (12/15) cases.
Alcohol, fungal dysbiosis in the gut and alcoholic liver disease
September 04 2017
Alcohol liver disease (ALD) due to chronic alcohol abuse is characterised by fatty liver and it can lead to severe complications such as alcohol hepatitis, fibrosis and cirrhosis. An-Ming Yang of UCSD, La Jolla, California, USA and many co-authors demonstrate the presence of fungal dysbiosis and systemic antigenaemia in the guts of mice and humans during chronic alcohol abuse (ref). Fungal overgrowth in the gut and translocation of fungal β-glucan into the systemic circulation was observed. These could be controlled by antifungal treatment which also improved the ALD.
Sporotrichosis is the most common subcutaneous mycosis in Peru
August 25 2017
A systematic review and meta-analysis to estimate the burden of subcutaneous mycoses in Peru showed that 99.7% of subcutaneous mycoses cases are caused by Sporothrix schenckii. Chromoblastomycosis, lobomycosis, and subcutaneous phaeohyphomycosis are reportedly rare mycoses in Peru and there were no cases of eumycetoma or subcutaneous zygomycosis reported.
Cryptococcal meningitis among other CNS infections
August 21 2017
In a 37 centre, 20 country study, Hakan Erdem, Ankara and colleagues examined the causes of central nervous system (CNS) infection and their outcomes. Among 2,583 patients seen in 24 months, 27 (1%) had cryptococccal meningitis, with only 50% of the cases having HIV infection. Nine of 14 (64%) had another immunosuppressed state, so overall 5 (19%) had no underlying condition.
Liposomal amphotericin B versus placebo to prevent invasive mycoses in acute lymphoblastic leukaemia
August 14 2017
In a multicenter, randomized, double-blind, placebo-controlled trial, Cornely et al. showed that liposomal amphotericin B (L-AMB) was not effective as prophylaxis against invasive fungal disease (IFD) in patients with newly diagnosed acute lymphoblastic leukaemia (ALL).