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Fungal keratitis in Scandinavia, a temperate climate

June 13 2014

Over 14 years, 25 cases of confirmed fungal keratitis were treated in 2 centres in Denmark—a population rate of >0.6/1,000,000 per year. Over half the cases were caused by Candida spp., which had a worse outcome. This frequency contrasts with subtropical and tropical areas in which Aspergillus and Fusarium species are more common.
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Increasing incidence of invasive fungal infections in France

June 10 2014

A new population-based analysis by Bitar et al. at the Institute of Health Surveillance, Paris, reveals an increasing incidence of invasive fungal infections (IFIs) in France. A national hospital database covering >95% of France’s hospitals was utilised in an epidemiological study, identifying hospital stays between 2001-2010 for which IFIs were the primary cause of admission. 35,876 cases were identified, excluding patients staying in the hospital more than once and inconsistently-recorded cases.
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Itraconazole versus trimethoprim-sulfamethoxazole (TMP-SMX) in paracoccidioidomycosis

May 27 2014

Paraoccidioidomycosis (PCM) is a systemic fungal infection native to subtropical areas of Latin America. It causes over 3000 new cases annually; of these patients, around 5% will die of the infection. Various therapeutic options have been used to successfully treat PCM including sulfonamide derivatives (e.g. trimethoprim-sulfamethoxazole; TMP-SMX) and azole antifungals (such as itraconazole). Previous literature and current Brazilian Consensus guidelines for PCM suggest that itraconazole may be more effective than TMP-SMX; however, there are few reports in the literature comparing efficacy of these two regimens.
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Limited availability of generic antifungals across the world

May 15 2014

In a global analysis, GAFFI has identified major gaps in antifungal drug provision for common fungal infections. From multiple sources—most directly from individual countries—it shows flucytosine availability in 24%, amphotericin B deoxycholate in 49%, itraconazole in 93% and fluconazole in 98% of countries (including PEPFAR provision). No antifungals are available in Afghanistan.
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Burden of serious fungal diseases presented at ECCMID for Czech Republic, Denmark, Germany, Hungary,

May 11 2014

The burden serious fungal disease from 6 European countries, Vietnam and Iraq, covering a total of 340 million people, has been presented at the ECCMID conference in Barcelona on May 10-13th 2014. The estimate from Vietnam is the first SE Asian country to be modelled. Notably different from other countries include high rates of Candida bloodstream infections in Denmark (8/100,000), increasing Pneumocystis pneumonia rates in the UK and Germany (0.94 and 1.2/100,000) and high rates of both chronic pulmonary aspergillosis (61/100,000) and tinea capitis (457/100,000) in Vietnam. Ukraine appears to have generally very high frequencies of several key infections.
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