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Epidemiological cut off values (ECVs) for species of Sporothrix - a step to defining resistance

September 26 2017

In a recent study by Ana Espinel-Ingroff et al, in vitro susceptibility testing by broth microdilution M38-A2 method for 875 strains of S. schenckii, S. brasiliensis, S. globosa and S.mexicana collected from 17 independent laboratories was done. The CLSI M38-A2 is a reference method for testing the susceptibility of filamentous fungi that cause invasive and cutaneous fungal infections to antifungal agents. The wild type susceptibility (MIC/MEC) distributions for 5 antifungals in clinical use were determined and the ECVs were obtained.
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1 in 9 patients lose an eyeball to fungal eye infections in Pakistan

September 19 2017

126 (11%) of the 1,130 patients with fungal keratitis (keratomycoses) lost their eyeballs in a recent report of a prospective 11 years study conducted by Professor S.I.A. Shah and colleagues at Chandka Medical College and Hospital, Larkana, Pakistan, from March 2005 to March 2016. Over 50% of the remainder effectively lost their sight.
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CURSO ONLINE EM MICROSCOPIA DE FUNGOS É LANÇADO PELA UNIVERSIDADE DE MANCHESTER

September 18 2017

Os cientistas estimam que dos 5 milhões de espécies de fungos existentes na Terra, cerca de 600 causem doenças no homem. Diagnosticar uma infeção fúngica grave em tempo real é um grande desafio e este curso tem como objetivo ensinar um método rápido de diagnóstico.
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About 10% of CNS cryptococcosis in India is caused by Cryptococcus gattii with 80% mortality

September 13 2017

About 10% of CNS cryptococcosis in India is caused by Cryptococcus gattii in a prospective 3 year study conducted by Shayanki Mukhopadhyay and colleagues at the National Institute of Mental Health and Neuro Sciences, Bangalore, India. A total of 199 cases of CNS cryptococcosis were diagnosed between January 2012 and December 2015, 20 (10%) of which were due to C. gattii. Most 75% (n=15) of the C. gattii-infected patients presented with meningitis and 25% (n=5) with a cryptococoma. Mortality was 80% in both cryptococcoma (4/5) and meningitis (12/15) cases.
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Alcohol, fungal dysbiosis in the gut and alcoholic liver disease

September 04 2017

Alcohol liver disease (ALD) due to chronic alcohol abuse is characterised by fatty liver and it can lead to severe complications such as alcohol hepatitis, fibrosis and cirrhosis. An-Ming Yang of UCSD, La Jolla, California, USA and many co-authors demonstrate the presence of fungal dysbiosis and systemic antigenaemia in the guts of mice and humans during chronic alcohol abuse (ref). Fungal overgrowth in the gut and translocation of fungal β-glucan into the systemic circulation was observed. These could be controlled by antifungal treatment which also improved the ALD.
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