Media Centre

Fungal prostatitis due to Cryptococcus and endemic mycoses

September 01 2020

One of the reasons for relapse of cryptococcal disease in AIDS is residual organisms in the prostate that are not eradicated by antifungal therapy (Larsen et al, 1989).

David Epstein and colleagues from the Southern California Permanente Group found 7 cases among >100,000 prostate biopsies (0.007%) and a further 8 cases in 2 other hospital systems. Biopsies showed fungi and granulomatous inflammation.

There were 7 cases of coccidioidomycosis, 3 of cryptococcosis and 1 of histoplasmosis among the 11 with any clinical data. The authors noted that prostatic blastomycosis and paracoccidioidomycosis are even rarer. The patients were asymptomatic or had non-specific symptoms.  Most had no concurrent extraprostatic loci of infection though some had known of a prior fungal infection, and all those with cryptococcal prostatic infection were immunocompromised.

FIGURE 2 (Epstein et al, 2020) Granulomatous prostatitis with numerous multinucleated histiocytes containing pale vacuoles with suggestion of features
suspicious for Cryptococcus (A). Gomori Methenamineā€Silver (GMS) stain shows numerous cryptococcal forms (B) in histiocytes. Prostate with
necrosis (right) (C). GMS stain shows numerous cryptococcal forms (D) in tissue